Imidazole CAS#288-32-4

CAS Number: 288-32-4
Chemical Formula: C3H4N2
Synonyms:

1H-IMIDAZOLE
1,3-DIAZA-2,4-CYCLOPENTADIENE
GLYOXALINE

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Detalles de producto

Imidazole CAS#288-32-4

Imidazole group denotes a heterocyclic organic compound whose molecule contains a five-membered hetero-aromatic ring of two non-adjacent nitrogen atoms, that a carbon atom is placed between two nitrogen atoms. Imidazole is the universally used trivial name for 1,3-azole. Earlier given names were glyoxaline and iminazole. The importance of this aromatic ring system is reflected by its presence in naturally occurring histidine, histamine and the purines, and in several classes of pharmaceuticals. Imidazole can act as a base and as a weak acid. It exists in two tautomeric forms with the hydrogen atom taking position between the two nitrogen atoms.

Imidazole Chemical Properties

Melting point	88-91 °C(lit.)
Boiling point	256 °C(lit.)
bulk density	500-600kg/m3
density	1.01 g/mL at 20 °C
vapor pressure	<1 mm Hg ( 20 °C)
refractive index	1.4801
Fp	293 °F
storage temp.	Store below +30°C.
solubility	H2O: 0.1 M at 20 °C, clear, colorless
form	crystalline
pka	6.953(at 25℃)
Specific Gravity	1.03
color	white
Odor	Amine like
PH	9.5-11.0 (25℃, 50mg/mL in H2O)
PH Range	9.5 - 11
Water Solubility	633 g/L (20 ºC)
λmax	λ: 260 nm Amax: 0.10 λ: 280 nm Amax: 0.10
Sensitive	Hygroscopic
Merck	14,4912
BRN	103853
Dielectric constant	23.0（Ambient）
Stability:	Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.
Cosmetics Ingredients Functions	BUFFERING
InChI	1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChIKey	RAXXELZNTBOGNW-UHFFFAOYSA-N
SMILES	c1c[nH]cn1
LogP	-0.02 at 25℃
CAS DataBase Reference	288-32-4(CAS DataBase Reference)
NIST Chemistry Reference	1H-Imidazole(288-32-4)
EPA Substance Registry System	Imidazole (288-32-4)

Safety Information

Hazard Codes	C,Xi,T
Risk Statements	36/38-63-34-22-20/21/22-61
Safety Statements	26-36/37/39-45-22-36-27-53
RIDADR	UN 2923 8/PG 3
WGK Germany	1
RTECS	NI3325000
Autoignition Temperature	480 °C
TSCA	TSCA listed
HazardClass	8
PackingGroup	III
HS Code	29332990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Repr. 1B Skin Corr. 1C
Hazardous Substances Data	288-32-4(Hazardous Substances Data)
Toxicity	LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie)

Product Application Of Imidazole CAS#288-32-4

Imidazole is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used ext ensively as a corrosion inhibitor on transition metals such as copper.It is used in organic synthesis and as an antiirradiationagent.
Imidazole has been used:
in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein.
in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography.
as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cell.

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